Cellular Imaging Systems

Cellular Imaging Systems

High-Content Screening (HCS) is an advanced technique that utilizes automated microscopy and sophisticated image analysis to explore cellular behaviors and functions in depth.

Examining multiple cellular parameters simultaneously—HCS offers a comprehensive view of how cells respond to different treatments and conditions.

Molecular Devices provide high-content imaging and HCS solutions, ranging from automated digital microscopy to high-throughput confocal imaging systems with modern machine learning analysis software.


High-content Imaging

Maximize workflow efficiency and experimental design.

  • ImageXpress HCS.ai
  • ImageXpress Confocal HT.ai
  • ImageXpress Micro Confocal
  • ImageXpress Micro 4
  • ImageXpress Pico

Imaging Acquisition & Analysis Software

Software which can solve complex image analysis problems by utilizing advanced artificial intelligence and customized analysis protocols.

  • MetaXpress Acquire Software
  • IN Carta Image Analysis Software
  • StratoMineR Software
  • CellReporterXpress Software
HCS.ai Confocal HT.ai Micro Confocal Micro 4 Nano Pico
ImageXpress HCS.ai ImageXpress Confocal HT.ai ImageXpress Micro Confocal ImageXpress Micro 4 ImageXpress Nano ImageXpress Pico
CAMERA • >5 mega pixel sCMOS sensor with large sensor size (224mm²)
• >3 log dynamic range with 16bit detector, 95% peak quantum efficiency
• >4 megaPixel sCMOS sensor
• >3 log dynamic range with 16bit detector
• >4 megaPixel sCMOS sensor
• >3 log dynamic range with 16bit detector
• >4 megaPixel sCMOS sensor
• >3 log dynamic range with 16bit detector
CMOS CMOS
OBJECTIVES • 6-position automated objective changer
• High NA air objectives: 2X–60X (up to 0.85 NA)
• Extra long working distance objectives 20X–60X (up to 0.7 NA)
• Water immersion (20x, 40x, 60x)
•Air (2x-100x)
• Water immersion (20x, 40x, 60x)
• Oil (40x, 60x, 100x)
• Air (1x-100x)
• Oil (40x, 60x, 100x)
• Water immersion (20x, 40x, 60x)
• Air (2x-100x)
• Oil (40x, 60x, 100x)
• Air (2x–60x) • Air (2.5x–63x)
AUTOFOCUS Hardware + Image Autofocus Hardware + Image Autofocus Hardware + Image Autofocus Hardware + Image Autofocus Hardware + Image Autofocus Hardware + Image Autofocus
PLATES SUPPORTED Up to 1536-well plates Up to 1536-well plates Up to 1536-well plates Up to 1536-well plates Up to 1536-well plates Up to 384-well plates
96-Well Plate Scan Time, 2 Colors, 1 Site/Well 1.5 min 2 min 2 min 2 min 4 min 8 min
Maximum Illumination Channels 7 7 5 5 5 6